(Adnkronos) - Rapidità d’azione e facilità di somministrazione i punti di forza di questa terapia orale per una patologia che può colpire a tutte le età e per le sue comorbidità, come ad esempio, l’alopecia areata.
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00:00If in the past it was thought that atopic dermatitis was a more frequent disease in children, with a prevalence ranging from 8% to 20% depending on the country of origin,
00:14there are also several levels of industrialization. Today it has become clear that in reality 8% of adults and 11% and more of the elderly suffer from atopic dermatitis.
00:24It is a somewhat invalidating disease, because in addition to the typical clinical signs in visible or sensitive areas of the body, such as face, head, neck, hands or genitals,
00:33it has as its most relevant symptom the pruritus, which in the case of the onset of the disease in childhood will accompany those who suffer from atopic dermatitis for life with negative consequences in study, work and social life.
00:44Today, however, as explained by Silvia Mariel Ferrucci, head of the Center for Allergological Dermatology of the Complex Structure of Dermatology at the IRCS Foundation, a large polyclinic in Milan,
00:54the situation is radically improving thanks to a new class of drugs, inhibitors.
00:59These new molecules, also called small molecules, are able to determine in a short time a clear improvement of both symptoms such as pruritus and pain, as well as clinical manifestations.
01:14And as we know, in the nodular pruritus, the pruritus is an important symptom that guides the disease.
01:22So if I can control the pruritus, I can break that vicious circle, pruritus-scratching, and therefore it leads to a reduction of the signs and symptoms of the disease.
01:33And therefore it determines an important improvement of the patient's quality of life.
01:39The main strengths of inhibitors underlined by Maddalena Napolitano, a professor of dermatology at the Federico II University of Naples, are in fact the rapidity of action and the ease of supply.
01:50Inhibitors have changed the approach to the management of atopic dermatitis because the characteristic of the inhibitor is the speed.
01:59They have an on-off mechanism, like a switch.
02:02When therapy is taken, it is a pill therapy, compared to biopharmaceuticals that are injected,
02:10when it is taken, already in the first 24, on average 48 hours, the effect of the therapy is seen.
02:17In fact, patients refer to the appearance of pruritus in the first 48 hours, which is the most important symptom of atopic dermatitis, the most invalidating for the patient.
02:28And already in the first month, a partial and progressive disappearance of the signs of dermatitis.
02:37So it is the rapidity, the characteristic effect.
02:41For Alessandra Narcisi, medical director of the complex operating unit of dermatology of IRCS Humanitas di Ruzzano in the province of Milan,
02:48she then studies in real life the safety of inhibitors available in two different dosages depending on their use,
02:55they have shown a very high level of safety in the treatment of atopic dermatitis and in their other dermatological indications, such as alopecia areata.
03:04In the few years that we have these drugs available, the first thing that surprised us was the great effectiveness on atopic dermatitis,
03:13in relieving the patient first of the symptoms, then pruritus and loss of sleep, and then in almost completely cleaning the skin.
03:21So the patient can regain a quality of life almost normal as if he did not have the disease.
03:27But not only.
03:28Often the atopic patient is also affected by rhinitis, rhinitis, asthma.
03:34The inhibitors at this time do not have the indication for these pathologies,
03:38but from our real life that we have recently published in an accredited scientific journal,
03:44they still have an improvement of these comorbidities during the course of therapy with inhibitors.