(Adnkronos) - Contro la dermatite atopica, “i cosiddetti farmaci Jak-inibitori”, riducono il processo infiammatorio bloccando “il segnale delle citochine” che “non possono più effettuare la loro azione dannosa nei confronti del tessuto epidermico”. I pazienti tornano “a una vita normale, senza più i problemi di pruriti, rossori e fastidi”. Queste terapie “sono in grado, molto spesso, di determinare una remissione completa, o quasi, di tutti i sintomi”. Così Vito Di Lernia, responsabile della Struttura Semplice Dermatologia Immunologica Asl Reggio Emilia con Adnkronos Salute fa il punto sulla malattia che interessa “circa il 5-7% della popolazione adulta e addirittura il 20% della popolazione pediatrica”.
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00:00Genes, familiarity, altered skin barrier, water imbalance, are the elements that can lead to the development of atopic dermatitis, chronic inflammatory disease, which is accompanied by a redness, pruritus and flaking of the skin, which interests about 5-7% of the adult population and even 20% of the pediatric population.
00:30In recent years, atopic dermatitis therapy has made big steps forward, very effective drugs have been made available to the doctor for treatment,
00:44starting with monoclonal antibodies, which have the function of blocking a single cytokine, and then drugs that act on different inflammatory cytokines,
01:00which in fact atopic dermatitis is due to a very complex inflammatory process that involves different cytokines and therefore has the advantage of having drugs that are able to act on these different cytokines involved in atopic dermatitis,
01:17whose expression is in fact blocked, and these are the so-called check inhibitors drugs that block these enzymes that transmit the signal of the cytokines,
01:29for which the cytokines remain, let's say, present in the circle, but can no longer perform their harmful action against the epidermal tissue.
01:38The disease has a strong impact on the quality of life.
01:42These therapies are very often able to determine a complete or almost complete remission of symptoms.
01:50There are drugs that act a little slower and drugs such as check inhibitors that are often able to act within a few weeks,
02:01first of all by immediately removing the pruritus, and then in the following days also the inflammatory manifestations, that is, the thickening of the lesions,
02:11so patients not only sometimes change their appearance, let's say, of their skin, because they lose the inflammatory clots,
02:20the skin returns to normal, especially the patient returns to rest, returns to live his life as it may not have happened months or even years ago.
02:31If it is a chronic disease, the therapy, according to the expert, must be maintained, because otherwise the dermatitis could reoccur with a recidiva.