• 2 hours ago
(Adnkronos) - “L’avvento di nuove terapie estremamente mirate, come mepolizumab che va a bloccare l'interleuchina-5 circolante, ci permette di targettare, in maniera estremamente specifica, la via dell'infiammazione di tipo 2 riducendo rapidamente l’eosinofilo  e di conseguenza, l’esposizione al cortisone”. Lo dichiara il professor Roberto Padoan, responsabile del Centro vasculiti Uoc di Reumatologia Azienda ospedaliera di Padova, a valle dell’incontro stampa “Egpa: opportunità di trattamento con mepolizumab e ruolo dello pneumologo”, organizzato a Milano da Gsk e dedicato alla granulomatosi eosinofilica con poliangite (Egpa).

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00:00What are the risk factors in the pathogenesis of the disease?
00:04Among the risk factors, or better, in the pathogenesis of the disease,
00:08today we are still studying a lot.
00:11Unfortunately, we do not have a precise answer.
00:13We know that the patients affected by this disease,
00:16whose acronym is IGPA,
00:18are patients who have a genetic component,
00:21so they have genetic alterations located at several levels
00:25that predispose the appearance, the development of the disease.
00:29These are genes, on the one hand,
00:31that regulate the path of autoimmunity
00:35and, on the other, the path of type 2 inflammation,
00:38the interleukin-5.
00:40The therapeutic scenario of these patients is rapidly changing.
00:43In recent years, if before we had to rely mainly
00:47on the use of cortisone and conventional immunosuppressants,
00:51the advent of new therapies,
00:53extremely targeted, such as mepolizumab,
00:55which blocks the circulating interleukin-5,
00:58allows us to target in an extremely specific way
01:01the path of type 2 inflammation,
01:03rapidly reducing the circulating and tissue eosinophil
01:08thus controlling all those eosinophilic manifestations
01:11that characterize the relapses that these patients have.
01:15This therefore allows us to significantly reduce
01:18the exposure to cortisone
01:20and improve the quality of life of these patients.

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