(Adnkronos) - "La miastenia gravis generalizzata è una patologia estremamente eterogenea, il suo sintomo cardine è l'affaticabilità muscolare che interessa diversi distretti muscolari compresi quelli della deglutizione e della respirazione". Lo ha spiegato Raffaele Iorio, neurologo presso l'università Cattolica del Sacro Cuore Policlinico Gemelli di Roma in occasione dell'incontro "Una nuova gestione della miastenia gravis generalizzata: approvato ravulizumab per il trattamento dei pazienti adulti" che si è tenuto a Milano per l’arrivo, con il rimborso di Aifa, di ravulizumab, il farmaco per il trattamento di pazienti adulti affetti da miastenia gravis generalizzata positivi agli anticorpi anti-recettore dell’acetilcolina.
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00:00What are the symptoms of cardiovascular disease?
00:04It is an extremely heterogeneous pathology.
00:07The cardiovascular symptom is muscular fatigue.
00:10It affects various muscular districts,
00:12from the bulbar nerve muscles,
00:14which are involved in phonation and degradation,
00:16to the extraocular muscles,
00:18which are involved in eye movements,
00:20the articular muscles,
00:21and the muscles that are also involved in breathing.
00:24Clinical heterogeneity is an important challenge,
00:27because the patient may have a variability of clinical manifestations,
00:31so the doctor's job is to properly interpret the clinical variability
00:35and to administer the appropriate therapies.
00:38Carbolizumab is a humanized monoclonal antibody
00:42specific for the C5 fragment of the complement.
00:45The complement has a fundamental role in serious myasthenia,
00:48as it is activated by specific autoantibodies
00:50for the receptor of acetylcholine,
00:53and the activation of the complement has the consequences of atheria,
00:56as it alters the morphology of neuromuscular junction,
00:59thus preventing the transmission of the complement.