• 3 days ago
@doctormohdasif|"new research on migraine raise the prospects of better therapies"
Are there new acute treatments for migraine? How do they compare to older treatments?
The newest short-term migraine treatments are the CGRP antagonists ubrogepant, rimegepant (which has a dual indication for both acute and preventive migraine treatment), and zavegepant (Zavzpret).

As discussed above, these medications have a favorable side effect profile and have not been shown to increase cardiovascular or bleeding risk, which may occur with some of the older treatments (such as triptans or nonsteroidal anti-inflammatory drugs).

Lasmiditan (Reyvow), while proven effective for acute treatment of migraine and considered safe in patients with cardiovascular disease, is known to cause dizziness and driving impairment.

Therefore, patients given this medication should not drive or operate potentially hazardous machinery for at least 8 hours after taking this medication.

What is CGRP? How is research on CGRP changing migraine treatment?
CGRP stands for calcitonin gene-related peptide. It’s a neuropeptide (brain chemical) that’s released from nerves and arteries and found to be elevated during migraine attacks, thus mediating pain during a migraine episode.

The discovery of CGRP’s role in migraine has revolutionized migraine treatment. CGRP antagonists act to block CGRP, thereby decreasing migraine symptoms or preventing them altogether.

Current research in this field has focused on different CGRP-targeted therapies, such as:

monoclonal antibodies, including:
erenumab
galcanezumab-gnlm
fremanezumab
eptinezumab-jjmr
small, gepant molecules, including:
ubrogepant
rimegepant
atogepant
zavegepant
Are there new delivery systems for migraine treatments? How do they affect treatment?
The latest migraine treatments include:

at-home injections, such as erenumab, galcanezumab-gnlm, fremanezumab (Ajovy)
orally disintegrating tablets (rimegepant)
IV infusions (eptinezumab-jjmr)
intranasal sprays (zavegepan)
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