• 10 months ago
Bryan Johnson is the self-proclaimed “most measured person in human history.”

Johnson, who became a millionaire selling his online payments startup to PayPal for $800 million, is the new poster boy for an old Silicon Valley obsession: “biohacking” your body to extend your lifespan. He takes routine measurements of everything from his blood to his stool as part of his anti-aging quest.

But Johnson told Forbes he believes there is one “gold standard” measurement tool to rule them all: the full-body MRI.

While startup Ezra and biohackers are trying to make MRIs mainstream, medical experts are concerned the full-body scans could do more harm than good — setting up people who have no specific risk of cancer or another illness for overtreatment and overdiagnosis.

Read the full story on Forbes: https://www.forbes.com/sites/rashishrivastava/2024/02/10/meet-the-bryan-johnson-approved-ai-full-body-mri-startup-that-just-raised-21-million/?sh=5021668145b2

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Transcript
00:00 Here's your Forbes Daily Briefing for Wednesday, February 14.
00:05 Today on Forbes, meet the Brian Johnson-approved AI full-body MRI startup that just raised
00:12 $21 million.
00:15 Brian Johnson is the self-proclaimed "most measured person in human history."
00:20 Johnson, who became a millionaire selling his online payments startup to PayPal for
00:26 $800 million, is the new poster boy for an old Silicon Valley obsession, so-called "biohacking"
00:33 your body to extend your lifespan.
00:36 He takes routine measurements of everything from his blood to his stool as part of his
00:40 anti-aging quest.
00:43 But Johnson told Forbes he believes there is one "gold standard" measurement tool to
00:47 rule them all—the full-body MRI.
00:51 The medical imaging technique uses powerful magnets to generate highly detailed pictures
00:56 of your insides, including organs, bones, joints, and blood vessels.
01:01 Johnson loves them.
01:02 He said, "I just did an MRI on every joint in my body in preparation for stem cell therapy.
01:08 I'm doing one on my brain.
01:09 I'm using it to quantify my body muscle and fat.
01:12 In the next month, I'll be doing six MRIs."
01:17 One of his go-to providers of the service is New York-based startup Ezra, which uses
01:22 artificial intelligence to speed up the process, with the goal of making full-body scans accessible
01:27 enough that people get them regularly.
01:31 Usually MRIs are done for a specific reason—targeting a specific area of the body.
01:36 But for Ezra's founder and CEO, Ami Ghal—a biohacker and longevity enthusiast himself—regular
01:43 full-body scans should be a universal pre-screening tool—a way to catch any potential condition
01:47 you might have—from cancer to bladder stones—early enough to treat it.
01:52 Now, Ezra has announced a fresh $21 million in venture funding to take full-body scans
01:58 mainstream.
01:59 With $41 million in total funding, Ezra is now valued between $100 million and $150 million,
02:06 according to a person in a position to know.
02:09 Ghal said that since Ezra was founded in 2018, 7,000 people have done its full-body scans,
02:15 which cost $2,500 a pop and aren't covered by insurance.
02:20 About one-third of them are "the Brian Johnsons of the world"—wealthy biohackers who work
02:25 in tech.
02:26 The rest are what he calls the "cancer conscious."
02:30 But medical experts are concerned that full-body MRI scans could do more harm than good for
02:35 the majority of patients, setting up people who have no specific risk of cancer or another
02:40 illness for over-treatment and over-diagnosis.
02:44 Not to mention the skyrocketing costs of a bunch of unnecessary follow-up procedures.
02:49 Ghal said Ezra offers a "screening" full-body scan, and if it shows any indication of cancer
02:54 or one of 500 conditions Ezra looks for, it would be a follow-up diagnostic exam outsourced
03:00 to the patient's regular doctor.
03:02 He said, "If you ask 10 people on the street, 'Would you like to do a scan that might require
03:07 you to do a follow-up scan?' or 'Would you like to die of cancer?'
03:11 pretty much all of them will say, 'Give me the follow-up scan.'"
03:15 While this argument is logical and appeals to the average person, it's not grounded in
03:19 science, according to Matthew Davenport, a radiologist and professor at the University
03:24 of Michigan.
03:26 Professor Davenport told Forbes, "Not all cancer is the same.
03:30 Depending on the organ, anywhere from 15 to 75 percent of cancers are indolent."
03:36 Indolent is a medical term meaning that the cancer has a very low likelihood of spreading
03:40 or shortening their life expectancy.
03:44 This is why medical guidelines around screening for cancer always take into account the patient's
03:47 probability of getting cancer in the first place.
03:50 For example, does this person have a family history of cancer, or live or work in an environment
03:55 where they might be exposed to toxins?
03:58 Otherwise, this leads to what Davenport calls a "cascade of care," meaning work-ups, diagnoses,
04:05 biopsies and treatments that the patient might not even need in the first place.
04:10 He said, "It makes me sad, because I think these companies are preying on people's vulnerabilities
04:15 and fears.
04:16 Now they start living with this idea that they have something lurking in their body,
04:19 which never would have harmed them in the first place if it hadn't been detected."
04:25 For full coverage, check out Rashi Srivastava and Katie Jennings' piece on Forbes.com.
04:31 This is Kieran Meadows from Forbes.
04:33 Thanks for tuning in.
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