First of its Kind Medicine Approved for A Chronic Lung Disease

  • 4 days ago
In the United States, more than 10 million people over the age of 40 live with chronic obstructive pulmonary disease (COPD), a chronic lung disease that limits air flow and causes breathing-related symptoms. COPD primarily affects people aged 40 and older, with current and former smokers having a higher risk of developing the disease. Patients with COPD have various symptoms that impact their daily life, including persistent cough and breathlessness. Those living with the disease often experience exacerbations, or flare ups, of their symptoms which may reduce lung function and can impair their ability to perform routine activities such as getting dressed, walking up stairs and going to work. Each time a patient experiences an exacerbation, there may be permanent, irreversible lung damage. Additionally, a subset of people living with COPD also have a high number of a type of white blood cell, called blood eosinophils, that can contribute to COPD. These patients may be at increased risk for exacerbations and even hospitalizations due to their condition. Although there's been some progress in the treatment of COPD, there has been a strong unmet need for novel treatment approaches, particularly for patients with inadequately controlled COPD and an eosinophilic phenotype. A first-of-its-kind treatment was recently approved to use with other medicines and was shown in clinical trials to help reduce COPD exacerbations, while improving patients' ability to breathe and their health-related quality of life. The approval of this innovative treatment provides patients, their caregivers and physicians with a new option to treat this chronic disease. Professor of Medicine in the Division of Pulmonary and Critical Care at the University of Michigan, Dr. MeiLan Han joined us to discuss the impact inadequately controlled COPD has on daily life and a new breakthrough treatment .
Transcript
00:00Hi, my name is Dr. Meilan Han, and I'm a professor of pulmonary medicine at the University of
00:10Michigan in Ann Arbor, and I'm here today to talk about COPD.
00:14So, COPD is a progressive lung disease.
00:17It causes significant damage to the lungs, and it makes it really hard for patients to
00:21do normal things, like walk up the stairs or even get dressed in the morning.
00:26But I'm excited to be partnering with Sanofi and Regeneron to talk about a new treatment
00:32option that's now available for patients.
00:34It's called dupilumab, also goes by the name dupixan, and it treats a very specific type
00:40of inflammation in COPD that we can identify through a white blood cell called eosinophils.
00:46Patients who have high levels of eosinophils are at increased risk for these frequent exacerbations
00:51or flare-ups, where patients suddenly get more short of breath and need treatment with
00:56antibiotics or steroids.
00:59And dupixan, when added to a patient's normal inhaled medications, can really help to reduce
01:05the frequency of these flare-ups.
01:08Now, it's not a reliever medication.
01:11Patients still need to use their inhaled rescue medications.
01:14But over time, dupixan can really help to decrease the eosinophilic inflammation and
01:20reduce the frequency of these flare-ups.
01:22Now, as a physician, I'm excited to have a new treatment option available for patients.
01:28Patients have been asking me for years if there's something else on top of the standard
01:32medications I'm already giving them that could provide even more benefit.
01:37And unfortunately, I just haven't had a lot to offer patients until now.
01:41So I am really excited about this potential treatment option for patients with eosinophilic
01:47phenotype of COPD.
01:49Now, as with any medication, it's always about risk and benefit.
01:54So there's definitely more information on the website, dupixant.com, but things patients
02:00should know.
02:01Obviously, if you're allergic to dupixant, you shouldn't take it.
02:04Other side effects that have been reported include eye problems, joint aches, and muscle
02:10pain.
02:11The first place patients really should go is to talk to their doctor, ask them if they've
02:16ever had their eosinophil level checked, and whether dupixant might be right for them.

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